OR6-006 – IL36RN alleles in skin auto-inflammation
نویسندگان
چکیده
Results We found IL36RN recessive mutations in patients with GPP (7/84) and localised pustular psoriasis (2/9 cases of Acrodermatitis Continua of Hallopeau and 3/139 cases of plamar-plantar pustulosis), but not among PV cases. Of note, we also identified several affected individuals who carried a single heterozygous mutation. In fact, we uncovered a significant enrichment of heterozygous IL36RN alleles among patients with pustular psoriasis (frequency in cases 1.4% vs. 0.3% in controls, P=0.004), but not among subjects with PV (0.4% cases vs. 0.3% controls, P=0.77).
منابع مشابه
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2013